A mounting flange is included standard on the axial port of all MS260i spectrographs, easily converting into a UV spectrometer, UV-VIS spectrometer, or VIS-IR spectrometer.Ī key performance parameter for the CCD is the maximum S/N achievable by the detector.
By using the 77439 mounting flange, it can be connected to the popular Oriel MS125 spectrograph.
Oriel multispec 77400 how to#
Read more about how to correctly acknowledge RSC content.The 78855 Oriel ® LineSpec is a 2048 pixel CCD detector operating from 200 to 1100 nm. Please go to the Copyright Clearance Center request page. In a third-party publication (excluding your thesis/dissertation for which permission is not required) If you want to reproduce the whole article If you are the author of this article, you do not need to request permission to reproduce figuresĪnd diagrams provided correct acknowledgement is given. Provided correct acknowledgement is given. If you are an author contributing to an RSC publication, you do not need to request permission To request permission to reproduce material from this article, please go to the
Oriel multispec 77400 skin#
In conclusion, the data from the present study indicate that improving ALA-based PDT of skin lesions might be achieved by elevating the skin temperature during the ALA application.Įffect of elevating the skin temperature during topical ALA application on in vitro ALA penetration through mouse skin and in vivo PpIX production in human skin
In the second, third and fourth hours of ALA application, the E a for PpIX production proved to be significant, which indicates that the PpIX production in these time intervals is dominated by temperature-dependent processes. The E a value in the first hour of ALA application was not significant, indicating that the PpIX production in that period is dominated by processes that are not temperature dependent, like the passive diffusion of ALA across the stratum corneum. The overall activation energy ( E a) for PpIX production was obtained for each hour of the ALA application period from the fluorescence data using the Arrhenius equation. The fluorescence data from the in vivo experiment show that the PpIX fluorescence increases with increasing temperature of the skin during the application period. The penetration of ALA through the mouse skin was higher when its temperature was maintained at 37 ☌ than through skin that was kept at 32 ☌. The data from the experiment with the in vitro percutaneous penetration model clearly show that the penetration of ALA into skin is temperature dependent. The effect of skin temperature on PpIX production in human skin during ALA application was measured with in vivo fluorescence spectroscopy in temperature-controlled areas (5 different temperatures). The effect of skin temperature on in vitro ALA penetration into mouse skin was determined in an in vitro percutaneous penetration model at two different temperatures. Increased skin temperature may increase the (depth of) penetration of ALA into the skin, which may in turn increase PpIX production (in deeper layers). An approach to induce increased protoporphyrin IX (PpIX) production in aminolevulinic acid (ALA)-based photodynamic therapy (PDT) of skin lesions is to elevate the skin temperature during topical ALA application.